학력

2006 동국대학교 생물학과 (학사)

2008 광주과학기술원 생명과학과 (석사)

2013 광주과학기술원 생명과학과 (박사)

주요경력

2013-2015 University of Texas Southwestern Medical Center, Post-doc.

2015-2019 한국식품연구원 선임연구원

2020-현재 부산대학교 생명환경화학부 조교수

가입학회

한국생화학분자생물학회(KSBMB)

미국세포생물학회 (ASCB)

전공연구분야

[연구분야]

질환 유발 세포내 신호전달체계 및 신규 유전자 기전 규명

비만 및 당뇨에서 생기는 스트레스 조절 기전 규명

기능성 식의약 생물자원소재 발굴 및 작용점 조절 기전 규명

[강의분야]

생화학, 인체유전생리학, 유전공학, 생물공학

논문

[학위논문]

Functional characterization of Cereblon as a novel regulator of cellular metabolism

[국제학술지]
1. Peanut shell extract inhibits the development of dextran sulfate sodium (DSS)-induced colitis. Int Immunopharmacol. 70:235-240, 2019

2. 3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Br J Pharmacol. 175(23):4295-4309, 2018

3. Protective Effects of Tyrosol Against Oxidative Damage in L6 Muscle Cells. Food Sci Technol Res. 24(5):943-947, 2018

4. Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel. J Neurosci. 38(14):3571-3583, 2018

5. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 22(1):57-66, 2018

6. MMP-1 suppressing activity of high-molecular weight fraction isolated from the roots of Cynanchum wilfordii Hemsley. J Funct Foods. 40:329-335, 2018

7. Melandrii Herba Extract Attenuates H₂O₂-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells and Scopolamine-Induced Memory Impairment in Mice. Molecules. 22(10):E1646, 2017

8. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 113(31):8771-6, 2016

9. Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS. J Biol Chem. 291(24):12888-96, 2016

10. Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK. Biochim Biophys Acta- Mol Basis Dis. 1852(12):2662-70, 2015

11. Depletion of the cereblon gene activates the unfolded protein response and protects cells from ER stress-induced cell death. Biochem Biophys Res Commun. 458(1):34-9, 2015

12. Functional Effects of a Pathogenic Mutation in CRBN on the Regulation of Protein Synthesis via the AMPK-mTOR Cascade. J Biol Chem. 289(34):23343-5, 2014

13. Ablation of cereblon attenuates myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 447(4):649-54, 2014.

14. Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high fat diet-induced obesity and insulin resistance in mice. Diabetes. 62(6):1855-64, 2013

15. Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4. Biochem Biophys Res Commun. 427(3):618-22, 2012.

16. Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells. PLoS One. 7(4):e36185, 2012

17. Functional modulation of AMP-activated protein kinase by cereblon. Biochim Biophys Acta-Mol Cell Res. 1813(3):448-55, 2011

18. Induction of cereblon by NF-E2-related factor 2 in neuroblastoma cells exposed to hypoxia-reoxygenation. Biochem Biophys Res Commun. 3;399(4):711/5, 2010

특허

피놀렌산 고함유 모노갈락토실디아실글리세롤 제조방법 (출원번호 : 10-2017-0052397)

왕불유행 추출물을 유효성분으로 포함하는 조성물 (출원번호 : 10-2017-0132768)

고구마 추출물을 유효성분으로 포함하는 조성물 (출원번호 : 10-2018-0004951)

옥수수 수염 추출물을 함유하는 독성 저감용 조성물 (출원번호 : 10-2018-0077915)

미후등 추출물을 유효성분으로 포함하는 지방간 예방 또는 치료용 조성물

(출원번호 : 10-2019-0000374)

베르베린을 유효성분으로 포함하는 림프부종 예방, 개선 또는 치료용 조성물 및

림프관 생성 유도제 (등록번호 : 10-1956291)